GPR68: An Emerging Drug Target in Cancer

Target flexibility: an emerging consideration in drug discovery and design.

Department of General and Inorganic Chemistry, UniVersity of Parma, Via G.P. Usberti 17/A 43100, Parma, Italy, National Institute for Biosystems and Biostructures, Rome, Italy, Department of Medicinal Chemistry and Institute for Structural Biology & Drug DiscoVery, Virginia Commonwealth UniVersity, Richmond, Virginia 23298-0540, Department of Pharmaceutics, UniVersity of Parma, Via GP Usberti 2...

Heat shock protein 70 (hsp70) as an emerging drug target.

Adipocyte-Epithelial Interactions and Crohn's Disease - An Emerging Drug Target

Article history: Received 31 August 2017 Accepted 31 August 2017 Available online 5 September 2017 Takahashi et al. demonstrated a novel cellular axis involving intestinal epithelial cells (IECs) and adipocytes. Several properties of this axis were important. Firstly, they observed an increase in MMP-9 mRNA in IECs when co-cultured with adipocytes that had differentiated from murine embryonic f...

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics

Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity, and is accompanied by the increased energy requirements of proliferating cells. Mitochondria occupy a central position in cell life and death...

The proteasome--an emerging therapeutic target in cancer.

This is an exciting time for cancer therapeutics. The identification of promising molecular targets has led to the development of many exciting new drugs for which an antitumor mechanism of action has been clearly delineated. Given the recent major advances in our understanding of the biology of cancer cells, one might surmise that an era of truly rational therapeutics has arrived. Nevertheless...